Proliferating cell nuclear antigen, PCNA (IPR000730)

Short name: Pr_cel_nuc_antig

Overlapping homologous superfamilies


Family relationships



Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein [PMID: 2884104] that plays a key role in the control of eukaryotic DNA replication [PMID: 1346518]. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNA replication [PMID: 2565339]. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes [PMID: 1671766]. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.

Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [PMID: 10542158, PMID: 10438605] and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses.

GO terms

Biological Process

GO:0006275 regulation of DNA replication

Molecular Function

GO:0003677 DNA binding
GO:0030337 DNA polymerase processivity factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.