Family

Galactokinase (IPR000705)

Short name: Galactokinase

Overlapping homologous superfamilies

Family relationships

Description

Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [PMID: 3062381, PMID: 1438294]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts in adults [PMID: 1438294]. In yeast, the GAL3 gene product is required for the GAL4-mediated induction of other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown to be similar to the GAL1 protein [PMID: 3062381].

GO terms

Biological Process

GO:0046835 carbohydrate phosphorylation
GO:0006012 galactose metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0004335 galactokinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS
TIGRFAMs
PANTHER