-
Overview
Galactokinase (IPR000705)
Short name: Galactokinase
Overlapping homologous superfamilies
- Ribosomal protein S5 domain 2-type fold, subgroup (IPR014721)
- Ribosomal protein S5 domain 2-type fold (IPR020568)
Family relationships
- Mevalonate/galactokinase (IPR006206)
- Galactokinase (IPR000705)
- Galactokinase, bacterial (IPR022963)
- Galactokinase (IPR000705)
Description
Galactokinase catalyses the first reaction in the galactose metabolism pathway, the ATP-dependent phosphorylation of galactose, yielding galactose-1-phosphate [PMID: 3062381, PMID: 1438294]. Deficiency in this enzyme results in the disease galactosemia, which is responsible for the formation of cataracts in newborn babies, and is possibly responsible for presenile cataracts in adults [PMID: 1438294]. In yeast, the GAL3 gene product is required for the GAL4-mediated induction of other enzymes involved in galactose metabolism. The induction of GAL1 production then reinforces this process, increasing the expression of other galactose-inducible genes. GAL3 has been shown to be similar to the GAL1 protein [PMID: 3062381].
GO terms
Biological Process
GO:0046835 carbohydrate phosphorylation
GO:0006012 galactose metabolic process
Molecular Function
GO:0005524 ATP binding
GO:0004335 galactokinase activity
Cellular Component
No terms assigned in this category.
Contributing signatures
- PR00473 (GALCTOKINASE)
- TIGR00131 (gal_kin)
- PTHR10457:SF6 (PTHR10457:SF6)