Family

Casein kinase II, regulatory subunit (IPR000704)

Short name: Casein_kinase_II_reg-sub

Family relationships

None.

Description

Casein kinase, a ubiquitous well-conserved protein kinase involved in cell metabolism and differentiation, is characterised by its preference for Ser or Thr in acidic stretches of amino acids. The enzyme is a tetramer of 2 alpha- and 2 beta-subunits [PMID: 2666134, PMID: 1856204]. However, some species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta') [PMID: 7737972].

The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif [PMID: 7737972]. The beta subunit contains, in its central section, a cysteine-rich motif, CX(n)C, that could be involved in binding a metal such as zinc [PMID: 8027080]. The mammalian beta-subunit gene promoter shares common features with those of other mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase [PMID: 7737972].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019887 protein kinase regulator activity

Cellular Component

GO:0005956 protein kinase CK2 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
SMART
PRINTS
PANTHER
Pfam