Protein-L-isoaspartate(D-aspartate) O-methyltransferase (IPR000682)

Short name: PCMT

Overlapping homologous superfamilies

Family relationships


Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC: (PCMT) [PMID: 9253175] (which is also known as L-isoaspartyl protein carboxyl methyltransferase) is an enzyme that catalyses the transfer of a methyl group from S-adenosylmethionine to the free carboxyl groups of D-aspartyl or L-isoaspartyl residues in a variety of peptides and proteins. The enzyme does not act on normal L-aspartyl residues L-isoaspartyl and D-aspartyl are the products of the spontaneous deamidation and/or isomerisation of normal L-aspartyl and L-asparaginyl residues in proteins. PCMT plays a role in the repair and/or degradation of these damaged proteins; the enzymatic methyl esterification of the abnormal residues can lead to their conversion to normal L-aspartyl residues. The SAM domain is present in most of these proteins.

GO terms

Biological Process

GO:0006464 cellular protein modification process

Molecular Function

GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns