Pyridoxamine 5'-phosphate oxidase (IPR000659)

Short name: Pyridox_Oxase

Overlapping homologous superfamilies

Family relationships



Pyridoxamine 5'-phosphate oxidase (EC: is an enzyme that is involved in the de novo synthesis of pyridoxine (vitamin B6) and pyridoxal phosphate. It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P. The enzyme requires the presence of flavin mononucleotide (FMN) as a cofactor, although there is some evidence that coenzyme F420 may perform this role in some species [PMID: 20675471].

The sequences of the enzyme from bacterial (genes pdxH or fprA) [PMID: 1356963] and fungal (gene PDX3) [PMID: 7896706] sources show that this protein has been highly conserved throughout evolution. PdxH is evolutionary related [PMID: 8586283] to one of the enzymes in the phenazine biosynthesis protein pathway, phzD (also known as phzG).

GO terms

Biological Process

GO:0008615 pyridoxine biosynthetic process

Molecular Function

GO:0010181 FMN binding
GO:0004733 pyridoxamine-phosphate oxidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.