Family

DegT/DnrJ/EryC1/StrS aminotransferase (IPR000653)

Short name: DegT/StrS_aminotransferase

Family relationships

Description

This entry represents the 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn) that are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. Members of the family have the same structural fold as members of the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily [PMID: 10433690]. The AHBA_synfamily includes are involved in various biosynthetic pathways for secondary metabolites. The AHBA_synfamily includes StsA P72454, StsC P77952 and StsS [PMID: 9238101]. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyses the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin [PMID: 9238101]. Some other well studied proteins in this family are AHBA_synthase, the protein product of the pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this family are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of Gram-positive and Gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this family consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This family also includes several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this family [PMID: 12429098, PMID: 18247575, PMID: 16894611, PMID: 17456741, PMID: 9238101, PMID: 7748903, PMID: 9914259, PMID: 10223296, PMID: 10800595, PMID: 17504214, PMID: 17109392, PMID: 11933250, PMID: 10673430].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PIRSF
Pfam