Iodothyronine deiodinase (IPR000643)

Short name: Iodothyronine_deiodinase

Overlapping homologous superfamilies


Family relationships


Iodothyronine deiodinase (EC: (DI) [PMID: 7592917] is the vertebrate enzyme responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). All known DI are proteins of about 250 residues that contain a selenocysteine at their active site. Three types of DI are known, type I is commonly found in the liver and kidney [PMID: 8187873], type II is essential for providing the brain with the appropriate levels of T3 during the critical period of development, and type III (also known as thyroxine 5-deiodinase) is essential for the regulation of thyroid hormone inactivation during embryological development.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0004800 thyroxine 5'-deiodinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.