Viral ssDNA-binding protein (IPR000635)

Short name: Viral_ssDNA-bd

Overlapping homologous superfamilies

Family relationships



This entry includes the major DNA-binding protein (DBP, UL57 or ICP8) from Herpesviruses. DBP binds single-stranded DNA, and the region encompassing residues 368-902 contains the DNA-binding site [PMID: 10529391]. UL5, UL8 and UL52 genes encode an essential heterotrimeric DNA helicase-primase that is responsible for concomitant DNA unwinding and primer synthesis at the viral DNA replication fork. DBP may stimulate DNA unwinding and enable bypass of cisplatin damaged DNA by recruiting the helicase-primase to the DNA [PMID: 9593724]. DBP helps initiate DNA replication by binding to the origin-binding protein (UL9) [PMID: 8230421]. It also reorganizes the host nucleus leading to the formation of prereplicative sites and replication compartments [PMID: 26676794].

GO terms

Biological Process

GO:0006260 DNA replication

Molecular Function

GO:0003697 single-stranded DNA binding

Cellular Component

GO:0042025 host cell nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.