Family

Viral ssDNA-binding protein (IPR000635)

Short name: Viral_ssDNA-bd

Family relationships

None.

Description

Although the overall picture of Human cytomegalovirus (HHV-5) DNA synthesis appears typical of the Herpesviruses, some novel features are emerging. Six herpesvirus-group-common genes encode proteins that likely constitute the replication fork machinery, including a two-subunit DNA polymerase, a helicas-primase complex and a single-stranded DNA-binding protein [PMID: 9130047].

The Human herpesvirus 1 (HHV-1) single-strand DNA-binding protein ICP8 is a 128kDa zinc metalloprotein. Photoaffinity labeling has shown that the region encompassing residues 368-902 contains the single-strand DNA-binding site of ICP8 [PMID: 10529391]. The HHHV-1 UL5, UL8, and UL52 genes encode an essential heterotrimeric DNA helicase-primase that is responsible for concomitant DNA unwinding and primer synthesis at the viral DNA replication fork. ICP8 may stimulate DNA unwinding and enable bypass of cisplatin damaged DNA by recruiting the helicase-primase to the DNA [PMID: 9593724].

GO terms

Biological Process

GO:0006260 DNA replication

Molecular Function

GO:0003697 single-stranded DNA binding

Cellular Component

GO:0042025 host cell nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam