ATP-dependent (S)-NAD(P)H-hydrate dehydratase (IPR000631)

Short name: CARKD

Overlapping homologous superfamilies

Family relationships


Hydration of NAD(P)H to NAD(P)HX, which inhibits several dehydrogenases, is corrected by an ATP-dependent dehydratase and an epimerase. The ATP-dependent dehydratase has been identified as the product of the vertebrate Carkd (carbohydrate kinase domain) gene [PMID: 24611804]. In E. coli, it is found as the C-terminal domain of a bifunctional enzyme (YjeF) that also includes the epimerase and uses ADP instead of ATP [PMID: 21994945]. These enzymes are widespread in eukaryotes, prokaryotes, and archaea.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles