Major outer membrane protein, Chlamydia (IPR000604)

Short name: Major_OMP_Chlamydia

Overlapping homologous superfamilies


Family relationships



The major outer membrane protein of Chlamydia contains four symmetrically spaced variable domains (VDs I to IV). This protein maintains the structural rigidity of the outer membrane and facilitates porin formation, permitting diffusion of solutes through the intracellular reticulate body membrane. It is believed to play a role in pathogenesis and possibly adhesion. Along with the lipopolysaccharide, the major out membrane protein (MOMP) makes up the surface of the elementary body cell. Disulphide bond interactions within and between MOMP molecules and other components form high molecular weight oligomers. The MOMP is the protein used to determine the different serotypes.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0015288 porin activity
GO:0005198 structural molecule activity

Cellular Component

GO:0009279 cell outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.