Domain

THIF-type NAD/FAD binding fold (IPR000594)

Short name: ThiF_NAD_FAD-bd

Domain relationships

Description

This domain is a NAD/FAD-binding fold found in ubiquitin activating E1 family and members of the bacterial ThiF/MoeB/HesA family. It is repeated in Ubiquitin-activating enzyme E1 [PMID: 11713534, PMID: 15660128, PMID: 18662542].

Ubiquitin-activating enzyme (E1 enzyme) [PMID: 1647207, PMID: 1656558] activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin- conjugating enzymes (E2).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008641 small protein activating enzyme activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
Pfam