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Overview
TSC-22 / Dip / Bun (IPR000580)
Short name: TSC-22_Dip_Bun
Overlapping homologous superfamilies
None.
Family relationships
None.
Description
Several eukaryotic proteins are evolutionary related and are thought to be involved in transcriptional regulation. These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerisation. Proteins containing this signature include:
- Vertebrate protein TSC-22 [PMID: 9022669], a transcriptional regulator which seems to act on C-type natriuretic peptide (CNP) promoter.
- Mammalian protein DIP (DSIP-immunoreactive peptide) [PMID: 8982256], a protein whose function is not yet known.
- Drosophila protein bunched [PMID: 7555710] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
- Caenorhabditis elegans hypothetical protein T18D3.7.
GO terms
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Molecular Function
GO:0003700 DNA binding transcription factor activity
Cellular Component
No terms assigned in this category.