Family

TSC-22 / Dip / Bun (IPR000580)

Short name: TSC-22_Dip_Bun

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Several eukaryotic proteins are evolutionary related and are thought to be involved in transcriptional regulation. These proteins are highly similar in a region of about 50 residues that include a conserved leucine-zipper domain most probably involved in homo- or hetero-dimerisation. Proteins containing this signature include:

  • Vertebrate protein TSC-22 [PMID: 9022669], a transcriptional regulator which seems to act on C-type natriuretic peptide (CNP) promoter.
  • Mammalian protein DIP (DSIP-immunoreactive peptide) [PMID: 8982256], a protein whose function is not yet known.
  • Drosophila protein bunched [PMID: 7555710] (gene bun) (also known as shortsighted), a probable transcription factor required for peripheral nervous system morphogenesis, eye development and oogenesis.
  • Caenorhabditis elegans hypothetical protein T18D3.7.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
Pfam
PANTHER
ProDom