Domain

Oxidoreductase, molybdopterin-binding domain (IPR000572)

Short name: OxRdtase_Mopterin-bd_dom

Domain relationships

None.

Description

A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [PMID: 2015248] to share a few regions of sequence similarity. These enzymes include xanthine dehydrogenase (EC:1.1.1.204), aldehyde oxidase (EC:1.2.3.1), nitrate reductase (EC:1.7.1.1), and sulphite oxidase (EC:1.8.3.1). The multidomain redox enzyme NAD(P)H:nitrate reductase (NR) catalyses the reduction of nitrate to nitrite in a single polypeptide electron transport chain with electron flow from NAD(P)H-FAD-cytochrome b5-molybdopterin-NO(3). Three forms of NR are known, an NADH-specific enzyme found in higher plants and algae (EC:1.7.1.1); an NAD(P)H-bispecific enzyme found in higher plants, algae and fungi (EC:1.7.1.2); and an NADPH-specific enzyme found only in fungi (EC:1.7.1.3) [PMID: 2204158]. The mitochondrial enzyme sulphite oxidase (sulphite:ferricytochrome c oxidoreductase; EC:1.8.2.1) catalyses oxidation of sulphite to sulphate, using cytochrome c as the physiological electron acceptor. Sulphite oxidase consists of two structure/function domains, an N-terminal haem domain, similar to cytochrome b5; and a C-terminal molybdopterin domain [PMID: 9428520].

GO terms

Biological Process

GO:0042128 nitrate assimilation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam