Histone H2B (IPR000558)

Short name: Histone_H2B

Overlapping homologous superfamilies

Family relationships



Histone H2B is one of the five histones, along with H1/H5, H2A, H3 and H4. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [PMID: 16472024]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. Histones can undergo several different types of post-translational modifications that affect transcription, DNA repair, DNA replication and chromosomal stability.

The HBR (histone H2B repression) domain within the H2B N terminus is important for nucleosome assembly by histone chaperone FACT [PMID: 27369377].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns