Calponin repeat (IPR000557)

Short name: Calponin_repeat


Calponin [PMID: 8130072, PMID: 8144658] is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin MgATPase activity. Calponin is a basic protein of approximately 34 Kd. Multiple isoforms are found in smooth muscles. Calponin contains three repeats of a well conserved 26 amino acid domain. Such a domain is also found in vertebrate smooth muscle protein (SM22 or transgelin), and a number of other proteins whose physiological role is not yet established, including Drosophila synchronous flight muscle protein SM20, Caenorhabditis elegans unc-87 protein [PMID: 7929573], rat neuronal protein NP25 [PMID: 8015377], and an Onchocerca volvulus antigen [PMID: 7935620].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
PROSITE patterns