Acetohydroxy acid isomeroreductase C-terminal (IPR000506)

Short name: AcH_isomrdctse_C

Overlapping homologous superfamilies

Domain relationships



Ketol-acid reductoisomerase (KARI) or acetohydroxy acid isomeroreductase catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the essential branched side chain amino acids valine and isoleucine [PMID: 9218783]. The enzyme forms a tetramer of similar but non-identical chains, and requires magnesium as a cofactor. Most ketol-acid reductoisomerases prefer the NADPH cofactor to NADH, but NADH-utilizing enzymes has also been identified [PMID: 25172159].

GO terms

Biological Process

GO:0009082 branched-chain amino acid biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004455 ketol-acid reductoisomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.