Family

Bradykinin receptor family (IPR000496)

Short name: Brdyknn_rcpt

Family relationships

Description

Bradykinins are a family of short, structurally similar peptides that activate sensory fibres, contract venous smooth muscle, stimulate release of cytokines, induce connective tissue proliferation and mediate endothelium-dependent vasodilation [PMID: 10812256, PMID: 12755382]. Bradykinin antagonists are used in the treatment of inflammation, asthma, mild pain and endotoxic shock.

Bradykinin receptors are members of the seven transmembrane, rhodopsin-like G-protein coupled receptor family and are widespread in peripheral tissues. There are two bradykinins receptor subtypes: B1 and B2. It has also been proposed there could be further subtypes of the bradykinin receptor, including a tracheal B3 receptor but these, as yet have not been confirmed [PMID: 9112069, PMID: 9650825, PMID: 8075864].

This entry represents the bradykinin receptor family.

GO terms

Biological Process

GO:0007186 G-protein coupled receptor signaling pathway
GO:0006950 response to stress

Molecular Function

GO:0004947 bradykinin receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS