Protamine-2 (IPR000492)

Short name: PRM2

Overlapping homologous superfamilies


Family relationships



The protamines are a diverse family of small arginine-rich proteins that are synthesized in the late-stage spermatids of many animals and plants. They bind to DNA, condensing the spermatid genome into a genetically inactive state. The two protamines found in mammals, P1 and P2, are the most widely studied. Both P1 and P2 have been shown to be required for normal sperm function in primates and many rodents [PMID: 17903313].

This entry represents protamine 2 (PRM2), which is present in haploid spermatogenic cells of human, mouse and other primates. The protamine P2 gene codes for a P2 precursor, pro-P2 which is later processed by proteolytic cleavages in its N-terminal region to form the mature P2 protamines [PMID: 8513810].

GO terms

Biological Process

GO:0006323 DNA packaging
GO:0007286 spermatid development

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.