Protamine 2, PRM2 (IPR000492)

Short name: PRM2

Family relationships



Protamines P1 and P2 form a family of small basic peptides that represent the major sperm proteins in placental mammals. In human and mouse protamine P2 is one of the most abundant sperm proteins. Protamine 2 (PRM2) is a low molecular weight arginine-rich protein which is present in haploid spermatogenic cells of human, mouse and other primates. The protamine P2 gene codes for a P2 precursor, pro-P2 which is later processed by proteolytic cleavages in its N-terminal region to form the mature P2 protamines [PMID: 8513810].

Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.

GO terms

Biological Process

GO:0007283 spermatogenesis

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0000786 nucleosome
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.