Cation-independent mannose-6-phosphate receptor (IPR000479)

Short name: CIMR


The cation-independent mannose-6-phosphate receptor is a type I membrane protein responsible for transport of phosphorylated lysosomal enzymes from the golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds insulin growth factor. It contains 15 copies of a repeat.

GO terms

Biological Process

GO:0006810 transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0005737 cytoplasm
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.