Cation-independent mannose-6-phosphate receptor (IPR000479)

Short name: CIMR


The cation-independent mannose-6-phosphate receptor is a multi-functional transmembrane glycoprotein whose major function is to bind and transport M6P-bearing glycoproteins from the trans-Golgi network or the cell surface to lysosomes. It appears to mediate the uptake and processing of M6P-containing cytokines and peptide hormones, such as transforming growth factor-beta, leukemia inhibitory factor, and proliferin [PMID: 19251055]. It also binds and internalizes the insulin-like growth factor II [PMID: 16779663].

GO terms

Biological Process

GO:0007041 lysosomal transport

Molecular Function

GO:0051219 phosphoprotein binding
GO:0038023 signaling receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.