Barstar (barnase inhibitor) (IPR000468)

Short name: Barstar

Overlapping homologous superfamilies

Domain relationships



Barstar is a small single chain protein. Barnase is the extracellular ribonuclease IPR001887 of Bacillus amyloliquefaciens, and barstar its specific intracellular inhibitor [PMID: 2696173, PMID: 3050134]. Expression of barstar is necessary to counter the lethal effect of expressed active barnase.

The structure of the barstar consists of two layers of parallel beta-sheet of three strands. Barstar inhibits barnase by statically blocking the active site with a helix and adjacent loop segment [PMID: 8043575].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.