Family

Hydroxyethylthiazole kinase (IPR000417)

Short name: Hyethyz_kinase

Family relationships

None.

Description

Most microorganisms and plants can synthesise thiamin de novo [PMID: 19348578]. In this de novo pathway, the thiazole and pyrimidine moieties of thiamin are made separately and coupled together to form thiamin phosphate. For the thiazole moiety, 4-methyl-5-(2-hydroxyethyl)thiazole (THZ), the key salvage step is phosphorylation to give 4-methyl-5-(2-phosphonooxyethyl)thiazole (THZ-P). The enzyme hydoxyethylthiazole kinase (EC:2.7.1.50) is responsible for this step. Hydoxyethylthiazole kinase is encoded by thiM in Escherichia coli [PMID: 2542220] and other bacteria, and by the C-terminal region of bifunctional proteins in some cases, such as Saccharomyces cerevisiae, in which the N-terminal domain corresponds to the bacterial thiamine-phosphate pyrophosphorylase (EC:2.5.1.3), ThiE [PMID: 7982968, PMID: 20968298].

The Arabidopsis and maize genomes encode homologues of ThiM [PMID: 23816351].

GO terms

Biological Process

GO:0009228 thiamine biosynthetic process

Molecular Function

GO:0004417 hydroxyethylthiazole kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
PANTHER
Pfam
HAMAP
PRINTS
TIGRFAMs
PIRSF