ABC-2 transporter (IPR000412)

Short name: ABC_2_transport

Overlapping homologous superfamilies


Family relationships


ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which uses the hydrolysis of ATP to energise diverse biological import and export systems. ABC transporters are minimally constituted of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These regions can be found on the same protein (mostly in eukaryotes and bacterial exporters) or on two different ones (mostly bacterial importers) [PMID: 9873074]. But in a subgroup of exporters, the transmembrane region is encoded by a separated polypeptide, the ABC-2 type transport system integral membrane protein. The molecular size of this transmembrane protein is around 30 kDa. It is thought to contain six transmembrane regions, it either form homooligomeric channels or associate with another type of transmembrane protein to form heteroligomers. The function of the integral inner-membrane protein is to translocate the substrate across the membrane and seems to play an important role in substrate recognition [PMID: 10331089].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles