Peptide chain release factor class I (IPR000352)

Short name: Pep_chain_release_fac_I

Overlapping homologous superfamilies


Domain relationships



Peptide chain release factors (RFs) are required for the termination of protein biosynthesis [PMID: 8821264]. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RF activity. In prokaryotes there are two class I RFs that act in a codon specific manner [PMID: 2215213]: RF-1 (gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB) mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown to be part of a larger family [PMID: 1408743].

GO terms

Biological Process

GO:0006415 translational termination

Molecular Function

GO:0003747 translation release factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns