Domain

SNF2-related (IPR000330)

Short name: SNF2_N

Domain relationships

None.

Description

This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1) [PMID: 7651832, PMID: 14729263]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.

Proteins that contain this domain appear to be distantly related to the DEAX box helicases, however no helicase activity has ever been demonstrated for these proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam