Hedgehog, N-terminal signalling domain (IPR000320)

Short name: Hedgehog_signalling_dom

Overlapping homologous superfamilies

Domain relationships



Hedgehog proteins are a family of secreted signal molecules required for embryonic cell differentiation. They are synthesised as inactive precursors with an N-terminal signalling domain linked to a C-terminal autoprocessing domain. The three-dimensional structure of the autolytic domain of the hedgehog protein of shows similarity with the beta-strand core of intein splicing domains. It has hence been termed the hint (Hedgehog/Intein) domain [PMID: 9489693].

This entry represents the N-terminal domain of hedgehog proteins, which is responsible for signalling following cleavage from the C-terminal domain. Its structure has been solved, and reveals a tetrahedrally coordinated zinc ion that appears to be structurally analogous to the zinc coordination sites of zinc hydrolases, such as thermolysin and carboxypeptidase A [PMID: 7477329]. This putative catalytic site represents a distinct activity from the autoprocessing activity that resides in the carboxy-terminal domain.

GO terms

Biological Process

GO:0007267 cell-cell signaling

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.