Family

Pyrroline-5-carboxylate reductase (IPR000304)

Short name: Pyrroline-COOH_reductase

Family relationships

None.

Description

Pyrroline-5-carboxylate reductase(P5CR) (EC:1.5.1.2) [PMID: 2199815, PMID: 2107123] is the enzyme that catalyzes the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline. This enzyme is also able to convert delta-1-piperideine-6-carboxylate (P6C) into pipecolic acid [PMID: 24431009]; this activity is part of pathway for the biosynthesis of the cyclic tetrapeptide apicidin F in the fungus Fusarium fujikuroi [PMID: 25058475].

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006561 proline biosynthetic process

Molecular Function

GO:0004735 pyrroline-5-carboxylate reductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PROSITE patterns
TIGRFAMs
HAMAP