Peptidyl-prolyl cis-trans isomerase, PpiC-type (IPR000297)

Short name: PPIase_PpiC

Overlapping homologous superfamilies


Domain relationships



Peptidyl-prolyl cis-trans isomerase (EC: (PPIase or rotamase) is an enzyme that accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [PMID: 2186809]. Most characterised PPiases belong to two families, the cyclophilin-type and the the FKBP-type. A third family has been discovered [PMID: 7925971]. So far, the only biochemically characterised member of this family is the Escherichia coli protein parvulin (gene ppiC), a small (92 residues) cytoplasmic enzyme that prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P1 position of the peptides substrates.

This entry represents a conserved region that contains a serine which could play a role in the catalytic mechanism of these enzymes


GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003755 peptidyl-prolyl cis-trans isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles