Conserved Site

NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site (IPR000283)

Short name: NADH_UbQ_OxRdtase_75kDa_su_CS

Description

NADH:ubiquinone oxidoreductase (complex I) (EC:1.6.5.3) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane (NADH + ubiquinone = NAD+ + ubiquinol) [PMID: 1470679]. Complex I is a major source of reactive oxygen species (ROS) that are predominantly formed by electron transfer from FMNH(2). Complex I is found in bacteria, cyanobacteria (as a NADH-plastoquinone oxidoreductase), archaea [PMID: 10940377], mitochondria, and in the hydrogenosome, a mitochondria-derived organelle. In general, the bacterial complex consists of 14 different subunits, while the mitochondrial complex contains homologues to these subunits in addition to approximately 31 additional proteins [PMID: 18394423].

This entry represents the 75 kDa subunit from NADH:ubiquinone oxidoreductase. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 75 kDa (in mammals), which is the largest subunit of complex I and is a component of the iron-sulphur (IP) fragment of the enzyme. It seems to bind to two 4Fe-4S clusters (called N-3 and N-4).

GO terms

Biological Process

GO:0042773 ATP synthesis coupled electron transport
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008137 NADH dehydrogenase (ubiquinone) activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns
PROSITE patterns