Domain

PB1 domain (IPR000270)

Short name: PB1_dom

Overlapping homologous superfamilies

None.

Domain relationships

Description

The PB1 (Phox and Bem1) domain, comprising about 80 amino acid residues, is conserved among animals, fungi, amoebas, and plants. It functions as a protein binding module through PB1-mediated heterodimerization or homo-oligomerization [PMID: 17726178, PMID: 15590654, PMID: 11483498, PMID: 24706860].

The PB1 domains adopt an ubiquitin-like beta-grasp fold, containing two alpha helices and a mixed five-stranded beta sheet. The beta-sheet has a convex surface, and alpha1 fits into the cavity formed by the sheet. PB1 domains may display an acidic surface (type I), a basic surface (tape II), or both surfaces (type I/II) on opposite faces of the domain structure to allow for front-to-back orientation of multiple PB1 domains [PMID: 17726178, PMID: 15590654, PMID: 11483498, PMID: 24706860, PMID: 24710426].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles
SMART