Domain

PB1 domain (IPR000270)

Short name: PB1_dom

Domain relationships

None.

Description

The PB1 (Phox and Bem1) domain, comprising about 80 amino acid residues, is conserved among animals, fungi, amoebas, and plants. It functions as a protein binding module through PB1-mediated heterodimerization or homo-oligomerization [PMID: 17726178, PMID: 15590654, PMID: 11483498, PMID: 24706860].

The PB1 domains adopt an ubiquitin-like beta-grasp fold, containing two alpha helices and a mixed five-stranded beta sheet. The beta-sheet has a convex surface, and alpha1 fits into the cavity formed by the sheet. PB1 domains may display an acidic surface (type I), a basic surface (tape II), or both surfaces (type I/II) on opposite faces of the domain structure to allow for front-to-back orientation of multiple PB1 domains [PMID: 17726178, PMID: 15590654, PMID: 11483498, PMID: 24706860, PMID: 24710426].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
PROSITE profiles
Pfam