DNA-directed RNA polymerase, subunit N/Rpb10 (IPR000268)

Short name: RNAP_N/Rpb10

Overlapping homologous superfamilies

Family relationships



In eukaryotes, there are three different forms of DNA-dependent RNA polymerases (EC: transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consists of an oligomeric assemblage of 10 to 13 polypeptides. Archaebacterial subunit N (gene rpoN) [PMID: 7597027] is a small protein of about 8 kDa, it is evolutionary related [PMID: 8045907] to a 8.3 kDa component shared by all three forms of eukaryotic RNA polymerases (gene Rpb10 in yeast and POLR2J in mammals) as well as to African swine fever virus (ASFV) protein CP80R [PMID: 11831707].

This family includes both archaeal subunit N, also known as Rpo10 following the eukaryotic nomenclature [PMID: 19419240], and eukaryotic Rpb10. There is a conserved region which is located at the N-terminal extremity of these polymerase subunits; this region contains two cysteines that binds a zinc ion [PMID: 10841539].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.