Angiotensin II receptor family (IPR000248)

Short name: ATII_rcpt

Overlapping homologous superfamilies


Family relationships


Angiotensin II is a blood-borne hormone produced in the circulation, it is also formed in many tissues such as the brain, kidney, heart, and blood vessels, where angiotensin II functions as a paracrine and autocrine hormone. The known actions of angiotensin II are mediated through two angiotensin receptor subtypes, Angiotensin II receptor 1 and angiotensin II receptor 2, which are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family. These subtypes are important in the renin-angiotensin system, as they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II [PMID: 17346243]. They also stimulate increased fluid intake and regulate the neuroendocrine system [PMID: 17346243].

This entry represents the angiotensin II receptor family. It also includes the relaxin-3 receptor 2, also known as GPCR142 [PMID: 14522967], and the apelin receptor from lower vertebrates [PMID: 16750822].

GO terms

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.