Serpin B9/maspin (IPR000240)

Short name: Serpin_B9/Maspin

Overlapping homologous superfamilies

Family relationships


This family consists of serpin B5 (Maspin) and serpin B9. They are members of the serpin (SERine Protease INhibitor) family (MEROPS inhibitor family I4, clan ID).

Serpin B9 is an inhibitor of the granzyme B/perforin lytic pathway [PMID: 12792516]. Maspin is a non-inhibitory member of family [PMID: 8290962, PMID: 14705960]. Maspin is expressed in normal mammary epithelial cells but not in most mammary carcinoma cell lines. Analysis of human breast cancer specimens has revealed that loss of maspin expression occurs most frequently in advanced cancers, supporting the hypothesis that maspin functions as a tumour suppressor [PMID: 8290962].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004867 serine-type endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.