Domain

Cadherin, cytoplasmic domain (IPR000233)

Short name: Cadherin_cytoplasmic-dom

Domain relationships

None.

Description

Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation [PMID: 3061804]. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn [PMID: 9566976]. The cytoplasmic region is highly conserved in sequence and has been shown experimentally to regulate the cell-cell binding function of the extracellular domain of E-cadherin, possibly through interaction with the cytoskeleton [PMID: 3061804]. This domain is found upstream of the cadherin domain IPR002126.

GO terms

Biological Process

GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam