Angiotensinogen (IPR000227)

Short name: Angiotensinogen

Overlapping homologous superfamilies


Family relationships


Angiotensinogen is a component of the renin-angiotensin system (RAS), a hormone system that regulates blood pressure and fluid balance. It is also known as the renin substrate, and is a non-inhibitory member of the serpin family of proteinase inhibitors (MEROPS inhibitor family I4, clan ID, MEROPS identifier I04.953).

Angiotensinogen is catalytically cleaved by renin to produce angiotensin I in response to lowered blood pressure. Angiotensin converting enzyme (ACE), subsequently removes a dipeptide to produce angiotensin II, the physiologically active peptide, which functions in the regulation of volume and mineral balance of body fluids [PMID: 2476171, PMID: 15010016]. Angiotensin I and angiotensin II can be further processed to generate angiotensin III, which stimulates aldosterone release [PMID: 1132082], and angiotensin IV. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 [PMID: 10969042] and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4 [PMID: 18026570, PMID: 15283675].

Angiotensinogen is synthesised in the liver and secreted in plasma [PMID: 23, PMID: 9, PMID: 467805, PMID: 4675]. Angiotensinogen appears to be associated with a predisposition to essential hypertension; it is also associated with pregnancy-induced hypertension (pih) (preeclampsia), a heterogeneous disorder that complicates 5-7% of all pregnancies and remains a leading cause of maternal, foetal and neonatal morbidity and mortality [PMID: 8513325].

The entry represents the full precursor sequence of angiotensinogen.

GO terms

Biological Process

GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.