Family

Angiotensinogen (IPR000227)

Short name: Angiotensinogen

Family relationships

Description

Angiotensinogen is a component of the renin-angiotensin system (RAS), a hormone system that regulates blood pressure and fluid balance. It is also known as the renin substrate, and is a non-inhibitory member of the serpin family of proteinase inhibitors (MEROPS inhibitor family I4, clan ID).

Angiotensinogen is catalytically cleaved by renin to produce angiotensin I in response to lowered blood pressure. Angiotensin converting enzyme (ACE), subsequently removes a dipeptide to produce angiotensin II, the physiologically active peptide, which functions in the regulation of volume and mineral balance of body fluids [PMID: 2476171, PMID: 15010016]. Angiotensin I and angiotensin II can be further processed to generate angiotensin III, which stimulates aldosterone release [PMID: 1132082], and angiotensin IV. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 [PMID: 10969042] and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4 [PMID: 18026570, PMID: 15283675].

Angiotensinogen is synthesised in the liver and secreted in plasma [PMID: 23, PMID: 9, PMID: 467805, PMID: 4675]. Angiotensinogen appears to be associated with a predisposition to essential hypertension; it is also associated with pregnancy-induced hypertension (pih) (preeclampsia), a heterogeneous disorder that complicates 5-7% of all pregnancies and remains a leading cause of maternal, foetal and neonatal morbidity and mortality [PMID: 8513325].

GO terms

Biological Process

GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS