Interleukin-5 (IPR000186)

Short name: IL-5

Overlapping homologous superfamilies

Family relationships



This entry represents interleukin-5 (IL5), also known as eosinophil differentiation factor (EDF), is a lineage-specific cytokine for eosinophilpoiesis [PMID: 3498940, PMID: 8483502]. It regulates eosinophil growth and activation [PMID: 3498940], and thus plays an important role in diseases associated with increased levels of eosinophils, including asthma [PMID: 8483502]. IL5 has a similar overall fold to other cytokines (e.g., IL2, IL4 and GCSF) [PMID: 8483502], but while these exist as monomeric structures, IL5 is a homodimer. The fold contains an anti-parallel 4-alpha-helix bundle with a left handed twist, connected by a 2-stranded anti-parallel beta-sheet [PMID: 8483502, PMID: 2037074]. The monomers are held together by 2 interchain disulphide bonds [PMID: 2037074].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008083 growth factor activity
GO:0005137 interleukin-5 receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.