Active Site

Membrane dipeptidase, active site (IPR000180)

Short name: Dipep_AS

Description

This signature defines the active site of peptidases belong to the MEROPS peptidase family M19 (membrane dipeptidase family, clan MJ). The protein fold of the peptidase domain for members of this family resembles that of Klebsiella urease, the type example for clan MJ [PMID: 12144777].

Renal dipeptidase (rDP) (EC:3.4.13.19), also known as microsomal dipeptidase, is a zinc-dependent membrane dipeptidase that hydrolyses a wide range of dipeptides. It is involved in renal metabolism of glutathione and its conjugates. It is a homodimeric disulphide-linked glycoprotein attached to the renal brush border microvilli membrane by a GPI-anchor.

This active site signature contains the glutamate residue that has been shown [PMID: 8097406] to be important for the catalytic activity of rDP. rDP seems to be evolutionary related to hypothetical proteins in the PQQ biosynthesis operons of Acinetobacter calcoaceticus and Klebsiella pneumoniae.

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0016805 dipeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008235 metalloexopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns