Glucoamylase (IPR000165)

Short name: Glucoamylase

Overlapping homologous superfamilies

Family relationships


This entry represents glucoamylase (GA), also known as glucan 1,4-alpha-glucosidase, which belongs to family 15 (GH15) in the classification of glycosyl hydrolases.

GA catalyses the release of D-glucose from the non-reducing ends of starch and other oligo- or poly-saccharides. Studies of fungal GA have indicated 3 closely-clustered acidic residues that play a role in the catalytic mechanism [PMID: 1970434]. This region is also conserved in a recently sequenced bacterial GA [PMID: 1633799].

The 3D structure of the pseudo-tetrasaccharide acarbose complexed with glucoamylase II(471) from Aspergillus awamori var. X100 has been determined to 2.4A resolution [PMID: 8195212]. The protein belongs to the mainly-alpha class, and contains 19 helices and 9 strands.

GO terms

Biological Process

GO:0005976 polysaccharide metabolic process

Molecular Function

GO:0004339 glucan 1,4-alpha-glucosidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns