Prohibitin (IPR000163)

Short name: Prohibitin

Overlapping homologous superfamilies

Family relationships



This entry describes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of the SPFH (band 7) domain superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes [PMID: 17766116]. These microdomains, in addition to being stable scaffolds, may also be dynamic units with their own regulatory functions [PMID: 10542406, PMID: 16091845]. Prohibitin is a mitochondrial inner-membrane protein which may act as a chaperone for the stabilization of mitochondrial proteins. Human prohibitin forms a hetero-oligomeric complex with Bap-37 (prohibitin 2, an SPFH domain carrying homolog). This complex may protect non-assembled membrane proteins against proteolysis by the m-AAA protease [PMID: 11498003, PMID: 10207067]. Prohibitin and Bap-37 yeast homologs have been implicated in yeast longevity [PMID: 15489194] and in the maintenance of mitochondrial morphology. Sequence comparisons suggest that the prohibitin gene is an analogue of Cc, a Drosophila melanogaster gene that is vital for normal development [PMID: 21296110].

Genes that negatively regulate proliferation inside the cell are of considerable interest because of the implications in processes such as development and cancer [PMID: 1996099]. Prohibitin acts as a cytoplasmic anti-proliferative protein, is widely expressed in a variety of tissues and inhibits DNA synthesis. Studies have suggested that prohibitin may be a suppressor gene and is associated with tumour development and/or progression of at least some breast cancers [PMID: 1540973].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.