GGDEF domain (IPR000160)

Short name: GGDEF_dom

Domain relationships


This domain appears to be ubiquitous in bacteria and is often linked to a regulatory domain, such as a phosphorylation receiver or oxygen sensing domain. Its function is to synthesize cyclic di-GMP, which is used as an intracellular signalling molecule in a wide variety of bacteria [PMID: 15075296,PMID: 15716451]. Enzymatic activity can be strongly influenced by the adjacent domains. Processes regulated by this domain include exopolysaccharide synthesis, biofilm formation, motility and cell differentiation.

Structural studies of PleD from Caulobacter crescentus show that this domain forms a five-stranded beta sheet surrounded by helices, similar to the catalytic core of adenylate cyclase [PMID: 15569936].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles