Domain

Ras-association (IPR000159)

Short name: Ras-assoc

Domain relationships

None.

Description

Proteins with this domain are mostly RasGTP effectors and include guanine-nucleotide releasing factor in mammals [PMID: 8987396]. This factor stimulates the dissociation of GDP from the Ras-related RALA and RALB GTPases, which allows GTP binding and activation of the GTPases. It interacts and acts as an effector molecule for R-ras, K-Ras and Rap [PMID: 7972015].

The domain is also present in a number of other proteins among them the sexual differentiation protein in yeast that is essential for mating and meiosis and yeast adenylate cyclase. These proteins contain repeated leucine-rich (LRR) segments.

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART
PROSITE profiles