InterPro

Literature: Toll/interleukin-1 receptor homology (TIR) domain (IPR000157)

References used in this entry

• Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
  Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L.
  Nature 408 111-5 2000
  PMID: 11081518 Related citations
• Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
  Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE, Dower SK.
  J. Biol. Chem. 275 4670-8 2000
  PMID: 10671496 Related citations
• Toll signaling pathways in the innate immune response.
  Anderson KV.
  Curr. Opin. Immunol. 12 13-9 2000
  PMID: 10679407 Related citations
• IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
  Muzio M, Ni J, Feng P, Dixit VM.
  Science 278 1612-5 1997
  PMID: 9374458 Related citations
• TLR6: A novel member of an expanding toll-like receptor family.
  Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
  Gene 231 59-65 1999
  PMID: 10231569 Related citations
• T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family.
  Mitcham JL, Parnet P, Bonnert TP, Garka KE, Gerhart MJ, Slack JL, Gayle MA, Dower SK, Sims JE.
  J. Biol. Chem. 271 5777-83 1996
  PMID: 8621445 Related citations

Further reading

• Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling.
  Ohnishi H, Tochio H, Kato Z, Orii KE, Li A, Kimura T, Hiroaki H, Kondo N, Shirakawa M.
  Proc. Natl. Acad. Sci. U.S.A. 106 10260-5 2009
  PMID: 19506249 Related citations
• The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer.
  Nyman T, Stenmark P, Flodin S, Johansson I, Hammarstrom M, Nordlund P.
  J. Biol. Chem. 283 11861-5 2008
  PMID: 18332149 Related citations
• TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.
  Bin LH, Xu LG, Shu HB.
  J. Biol. Chem. 278 24526-32 2003
  PMID: 12721283 Related citations
• Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
  Sekine Y, Yumioka T, Yamamoto T, Muromoto R, Imoto S, Sugiyma K, Oritani K, Shimoda K, Minoguchi M, Akira S, Yoshimura A, Matsuda T.
  J. Immunol. 176 380-9 2006
  PMID: 16365431 Related citations
• An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2.
  Tao X, Xu Y, Zheng Y, Beg AA, Tong L.
  Biochem. Biophys. Res. Commun. 299 216-21 2002
  PMID: 12437972 Related citations
• Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections.
  Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL.
  Nat. Immunol. 3 91-7 2002
  PMID: 11743586 Related citations
• Toll-like receptors: a family of pattern-recognition receptors in mammals.
  Armant MA, Fenton MJ.
  Genome Biol. 3 REVIEWS3011 2002
  PMID: 12186654 Related citations
• Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
  Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA.
  Nature 413 78-83 2001
  PMID: 11544529 Related citations
• Drosophila MyD88 is an adapter in the Toll signaling pathway.
  Horng T, Medzhitov R.
  Proc. Natl. Acad. Sci. U.S.A. 98 12654-8 2001
  PMID: 11606776 Related citations
• The Toll-receptor family and control of innate immunity.
  Kopp EB, Medzhitov R.
  Curr. Opin. Immunol. 11 13-8 1999
  PMID: 10047546 Related citations
• Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector.
  Caplan JL, Mamillapalli P, Burch-Smith TM, Czymmek K, Dinesh-Kumar SP.
  Cell 132 449-62 2008
  PMID: 18267075 Related citations
• A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
  Medzhitov R, Preston-Hurlburt P, Janeway CA Jr.
  Nature 388 394-7 1997
  PMID: 9237759 Related citations
• The cloning and characterization of human MyD88: a member of an IL-1 receptor related family.
  Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, Sims JE.
  FEBS Lett. 402 81-4 1997
  PMID: 9013863 Related citations