Ciliary neurotrophic factor, CNTF (IPR000151)

Short name: Ciliary_neurotrophic_fac_CNTF

Overlapping homologous superfamilies

Family relationships



Ciliary neurotrophic factor (CNTF) is a member of the gp130 family of cytokines. CNTF is a survival factor for various neuronal cell types and seems to prevent the degeneration of motor axons after axotomy suggesting it may be a potential therapeutic for treating neurodegeneration and nerve injury. CNTF acts on oligodendrocytes by favoring their final maturation, and this effect is mediated through the 130kDa glycoprotein receptor common to the CNTF family and transduced through the Janus kinase pathway. The functional receptor complex of CNTF is composed of the CNTF receptor alpha (CNTFR), gp130 and the leukemia inhibitory factor receptor (LIFR).

The structure of CNTF is a four helical bundle [PMID: 7796798]. CNTF acts as a homodimer. Three regions on CNTF have been identified as binding sites for its receptors. The ligand-receptor interactions are mediated through the cytokine binding domains (CBDs) and/or the immunoglobulin-like domains of the receptors. However, in the case of CNTF, the precise nature of the protein-protein contacts in the signalling complex has not yet been resolved, but there is evidence that the membrane distal CBD (CBD1) of LIFR associates in vitro with soluble CNTFR in the absence of CNTF [PMID: 11943154, PMID: 12417647].

GO terms

Biological Process

GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
GO:0043524 negative regulation of neuron apoptotic process

Molecular Function

GO:0005127 ciliary neurotrophic factor receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.