Conserved Site

Nitrilase/cyanide hydratase, conserved site (IPR000132)

Short name: Nitrilase/CN_hydratase_CS


This family includes both nitrilases and cyanide hydratase. Nitrilases (EC: are enzymes that convert nitriles into their corresponding acids and ammonia. They are widespread in microbes as well as in plants where they convert indole-3-acetonitrile to the hormone indole-3- acetic acid. A conserved cysteine has been shown [PMID: 8419930, PMID: 1400390] to be essential for enzyme activity; it seems to be involved in a nucleophilic attack on the nitrile carbon atom. Cyanide hydratase (EC: converts HCN to formamide. In phytopathogenic fungi, it is used to avoid the toxic effect of cyanide released by wounded plants [PMID: 1382413].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns