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Overview
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Cross-references
High mobility group protein HMGA (IPR000116)
Short name: HMGA
Overlapping homologous superfamilies
None.
Family relationships
- High mobility group protein HMGA (IPR000116)
- High mobility group protein HMGA, plant (IPR031059)
- High mobility group protein HMGA1, mammal (IPR031079)
Description
This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [PMID: 14645522].
The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [PMID: 25281808].
GO terms
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Molecular Function
GO:0003677 DNA binding
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
Contributing signatures
- PR00930 (HIGHMOBLTYIY)