Phosphoribosylglycinamide synthetase (EC:184.108.40.206) (GARS) (phosphoribosylamine glycine ligase) [PMID: 2687276] catalyses the second step in the de novo biosynthesis of purine. The reaction catalysed by phosphoribosylglycinamide synthetase is the ATP-dependent addition of 5-phosphoribosylamine to glycine to form 5'phosphoribosylglycinamide:
ATP + 5-phosphoribosylamine + glycine = ADP + Pi + 5'-phosphoribosylglycinamide
In bacteria, GARS is a monofunctional enzyme (encoded by the purD gene). In
yeast, GARS is part of a bifunctional enzyme (encoded by the ADE5,7 gene) in conjunction with phosphoribosylformylglycinamidine cyclo-ligase (AIRS) [PMID: 3097325]. In higher eukaryotes, GARS is part of a trifunctional enzyme in conjunction with AIRS and with phosphoribosylglycinamide formyltransferase (GART), forming GARS-AIRS-GART [PMID: 2147474].
GO:0009113 purine nucleobase biosynthetic process
GO:0004637 phosphoribosylamine-glycine ligase activity
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