Ribonuclease P (IPR000100)

Short name: RNase_P

Overlapping homologous superfamilies

Family relationships



Ribonuclease P (EC: (RNase P) [PMID: 1689306, PMID: 1700778, PMID: 1374553] is a site specific endonuclease that generates mature tRNAs by catalysing the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. In bacteria RNase P is known to be composed of two components: a large RNA (about 400 base pairs) encoded by rnpB, and a small protein (119 to 133 amino acids) encoded by rnpA. The RNA moiety of RNase P carries the catalytic activity; the protein component plays an auxiliary, but essential, role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. The sequence of rnpA is not highly conserved, however there is, in the central part of the protein, a conserved basic region.

GO terms

Biological Process

GO:0008033 tRNA processing

Molecular Function

GO:0004526 ribonuclease P activity
GO:0000049 tRNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.