Serum amyloid A protein (IPR000096)

Short name: Serum_amyloid_A

Overlapping homologous superfamilies


Family relationships



The serum amyloid A (SAA) proteins comprise a family of vertebrate proteins that associate predominantly with high density lipoproteins (HDL) [PMID: 7504491, PMID: 8188253]. The synthesis of certain members of the family is greatly increased (as much as a 1000 fold) in inflammation; thus making SAA a major acute phase reactant. While the major physiological function of SAA is unclear, prolonged elevation of plasma SAA levels, as in chronic inflammation, however, results in a pathological condition, called amyloidosis, which affects the liver, kidney and spleen and which is characterised by the highly insoluble accumulation of SAA in these tissues. SAA are proteins of about 110 amino acid residues. The most highly conserved region is located in the central part of the sequence. The proteins are polymorphic, the various isoforms apparently capable of responding in different ways to different stimuli.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns