Family

High mobility group protein HMGN (IPR000079)

Short name: HMGN_fam

Family relationships

Description

This entry represents the HMGN family, whose members promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. HMGNs are expressed only in vertebrates [PMID: 25281808].

The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [PMID: 25281808].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0031492 nucleosomal DNA binding

Cellular Component

GO:0000785 chromatin
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PRINTS
SMART
Pfam