Family

Adenosylhomocysteinase (IPR000043)

Short name: Adenosylhomocysteinase

Family relationships

None.

Description

Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, EC:3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding. Since AdoHyc is a potent inhibitor of S-adenosyl-L-methionine dependent methyltransferases, AdoHycase plays a critical role in the modulation of the activity of various methyltransferases. The enzyme forms homotetramers, with each monomer binding one molecule of NAD+ [PMID: 9586999,PMID: 16061414,PMID: 11325033,PMID: 15165742].

GO terms

Biological Process

GO:0006730 one-carbon metabolic process

Molecular Function

GO:0004013 adenosylhomocysteinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP
PIRSF
SMART
CDD
Pfam
PANTHER
TIGRFAMs