Family

Adenosylhomocysteinase (IPR000043)

Short name: Adenosylhomocysteinase

Family relationships

None.

Description

Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase, EC:3.3.1.1) (AdoHcyase) is an enzyme of the activated methyl cycle, responsible for the reversible hydration of S-adenosyl-L-homocysteine into adenosine and homocysteine. This enzyme is ubiquitous, highly conserved, and may play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. AdoHcyase requires NAD+ as a cofactor and contains a central glycine-rich region which is thought to be involved in NAD-binding.

GO terms

Biological Process

GO:0006730 one-carbon metabolic process

Molecular Function

GO:0004013 adenosylhomocysteinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam
PANTHER
TIGRFAMs
HAMAP
PIRSF