Protein phosphatase 2A regulatory subunit PR55 (IPR000009)

Short name: PP2A_PR55

Overlapping homologous superfamilies

Family relationships



Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in many cellular processes, including the regulation of metabolic enzymes and proteins involved in signal transduction [PMID: 1849734, PMID: 1370560]. PP2A is a trimer composed of a 36 kDa catalytic subunit, a 65 kDa regulatory subunit (subunit A) and a variable third subunit (subunit B) [PMID: 1849734, PMID: 1370560]. Subunits B can be classified into three subfamilies, the R2/B/PR55/B55, the R3/B''/PR72/PR130/PR59 and the R5/B'/B56 families.

This entry represent the R2/B/PR55/B55 family, which exists in Drosophila melanogaster and yeast, and has up to three isoforms in mammals (alpha/beta/gamma) [PMID: 1849734, PMID: 1370560]. PR55 may act as a substrate recognition unit, or may help to target the enzyme to the correct subcellular location [PMID: 1849734]. In budding yeasts, it is also known as Cdc55, which is essential for the spindle assembly checkpoint (SAC) [PMID: 23886942]. In flies, it is also known as PP2A-twins, which collaborates with polo kinase for cell cycle progression and centrosome attachment to nuclei in Drosophila embryos [PMID: 21852958].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0019888 protein phosphatase regulator activity

Cellular Component

GO:0000159 protein phosphatase type 2A complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.